We are seeking a director-level leader to establish a new team for high throughput analysis of designed zinc finger nucleases and transcription factors in mammalian cells. The successful candidate will coordinate with our design and research teams to develop leads of unsurpassed activity and specificity for use in genome and cellular engineering therapies. Initial responsibilities will include hiring key personnel, developing a strategic vision around group competencies and scope, and establishing state of the art screening facilities and processes that exceed industry standards. An ability to establish and enforce high quality standards for data generation and capture is especially critical, as screening output will be used both for choosing therapeutic leads and as training sets for improving algorithms and processes for protein design. Ultimate responsibilities will extend to development of novel approaches for assessing new types of designed genome modifying factors as well as designed nucleases and transcription factors at unprecedented scales. The position will report directly to senior management, with responsibility for motivating group structure, staffing and capabilities in light of company goals. The position requires creativity, adaptability, and constant innovation in pursuit of company goals. The environment is exciting and fast-paced, and offers the opportunity to work and publish at the cutting edge of cellular engineering research.
Conceptualization and implementation of an HTS platform and processes that can support multiple, simultaneous therapeutic gene editing and gene regulation projects.
Establishment of a state of the art screening facility and processes that exceed industry standards.
Collaboration with design and research teams in development of key experimental and technical protocols, best practices, and LIMS, including systems for effective data capture, analysis, publication and interrogation.
Bachelor in a relevant life sciences or engineering field; advance degree preferred
5+ years’ of industry experience with demonstrated success in the use of high-throughput transfection and analysis to identify leads
Extensive experience with laboratory automation
A working knowledge of industry standards for screening processes and quality
Demonstrated ability to process and analyze screening data
Excellent presentation skills
Ability to work in a team-oriented, multidisciplinary environment, and to take on increasing responsibility over time
Hands-on cell culture experience, including transgene delivery and analysis
Experience working in GMP and ISO regulated environments
A working knowledge of protein structure, DNA binding proteins, vector development, genome editing, and gene therapy
Familiarity with next-generation DNA sequencing methods and data
Computer programming skills such as coding with Python and applying advanced Excel functions
The above reflects management’s definition of essential functions for this position, but does not restrict the tasks that may be assigned. The above duties are representative only; management may assign or reassign duties and responsibilities to this position at any time.
Sangamo was founded in 1995 as Sangamo BioSciences, Inc. in order to research new technologies for genome editing. Over two decades, Sangamo's scientists developed the most advanced, flexible and precise technologies available for gene-based therapies. In 2017, Sangamo is conducting new human clinical trials, including the first ever in vivo human genome editing studies. Reflecting this focus on t...he clinical development of new genomic therapies, in 2017 the Company announced a new name, Sangamo Therapeutics.
For Sangamo Therapeutics, science is a means to develop new medicines with the potential to transform the lives of patients living with serious genetic diseases. The Company's scientists are leaders in the discovery, research and development of technologies enabling gene-based therapeutic development. Sangamo expects its scientific investment will reliably generate new programs for human clinical development.