Faculty Positions in Autoimmunity and Inflammation Oklahoma Medical Research Foundation
Job Summary/Basic Function: The Division of Genomics and Data Sciences (GDS), an integral component of the Arthritis and Clinical Immunology (ACI) Research Program at the Oklahoma Medical Research Foundation (OMRF), seeks to understand the fundamental question of how genotype influences phenotype in autoimmune and inflammatory diseases. Ongoing research in the division includes investigations into the mechanisms by which long non-coding RNAs influence autoimmune cell gene expression and function; the genetic characterization of systemic lupus erythematosus, sarcoidosis, Sjögren's syndrome, multiple sclerosis, and rheumatoid arthritis; the impact of genetic variation on epigenome function and 3D chromatin topography in the context of autoimmunity and inflammation; and the application of statistical, bioinformatic, machine learning, deep learning, and text-mining approaches to define disease-associated gene networks. We invite qualified candidates that share our interests and mission for clarifying how genotype influences phenotype in the context of autoimmunity and inflammation to apply for established Assistant or Associate Member level positions (Assistant or Associate Professor equivalent).
GDS-ACI investigators have access to several outstanding OMRF Core facilities including the CAP-accredited Clinical Genomics Center, Quantitative Data Analysis Core, Immunophenotyping Core, Flow Cytometry and Cell Sorting Core, and Imaging Core. Extensive autoimmune disease and control sample collections are available in the CAP-accredited OMRF Biorepository: Sample Procurement and Processing Core, and growing longitudinal patient cohorts of SLE, UCTD, ILE, autoimmune disease pregnancy, rheumatoid arthritis, and multiple sclerosis are also available through state-of-the-art clinical facilities. A NIAID-designated Autoimmune Centers of Excellence (U19), NIAMS Oklahoma Rheumatic Diseases Research Cores Center (P30), NIGMS Oklahoma Shared Clinical and Translational Resources (U54), NIAID Autoimmunity Prevention Center (U01), NIAMS Oklahoma Sjögren's Syndrome Center of Research Translation (P50), and four NIH Centers of Biomedical Research Excellence (P20/P30) grants currently support ACI-GDS.
Selected candidates will receive a generous, multi-year startup package with significant, sustained salary and research support, as well as access to considerable departmental clinical and translational research infrastructure.
OMRF is a highly collaborative, efficiently administered, independent, not-for-profit biomedical research institute adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City. OMRF investigators enjoy close scientific interactions with OUHSC faculty and have the opportunity to participate in OUHSC graduate programs. Life in Oklahoma City offers low cost of living, easy commutes, a vibrant downtown with high quality restaurants, professional and collegiate sports teams, and numerous arts and entertainment venues. Strong candidates will demonstrate proficiency in creative thinking, designing experiments independently, interpreting assay results, summarizing findings, and assisting with manuscript preparation, grant writing, supervising graduate students and presenting data at national meetings.
Minimum Qualifications: Candidates must have an M.D. and/or Ph.D. degree in biological or biomedical science fields, and a minimum of 3 years of relevant post-doctoral research experience or training. Senior candidates will also be considered. Successful candidates must demonstrate research productivity with a strong publication record, and the capacity to define and implement an independent research program via the submission of a research plan/career goal statement or, ideally, with external, peer-reviewed ongoing funding. Selected candidates are expected to maintain a vigorous and independently funded research program that addresses fundamental questions in the field of genetics, genomics, epigenetics and/or data sciences in the general area of autoimmunity and/or inflammation.
Preferred Qualifications: Collaborative and creative candidates whose research interests complement and expand the GDS-ACI investigators' current research expertise will be given highest priority. Candidates with expertise in one or more of the following areas are of particular interest:
1. Large scale epigenome characterization and mechanisms; 2. The application of large scale CRISPR screens and/or massively parallel reporter assays; 3. The development of human model systems using inducible pluripotent stem cells; 4. Application of genetic engineering approaches to define molecular mechanisms influencing phenotypes; 5. Single cell transcriptomic and epigenomic technologies; 6. Approaches to data integration and visualization in genomic/epigenomic studies.
Special Instructions to Applicants: To apply, submit a completed application, including cover letter, resume/CV, future research plan (3 pages, NIH grant style), career goals, and three letters of recommendation with contact information to: GDSfaculty@omrf.org. Review of applications will begin immediately and continue until the position is filled. Preliminary, confidential inquiries may be referred to Dr. Patrick M. Gaffney, Head of the Division of Genomics and Data Sciences: Patrick-Gaffney@omrf.org.