The Ronald M. Loeb Center for Alzheimer’s Disease, directed by Alison Goate, at the Icahn School of Medicine at Mount Sinai is seeking a passionate individual to investigate the neuropathology and genetics of neurodegenerative tauopathies. The center uses advanced genomic and computational approaches to identify novel drivers of disease pathogenesis.
This NIH-funded project focuses on understanding the overlap between Alzheimer's disease, Parkinson’s disease, and tauopathies. The candidate will join a highly productive team that includes geneticists, computational biologists, cell biologists, and physician-scientists. The successful candidate will play an active role in deploying next-generation sequencing data (DNA/RNA) and correlating results with novel endophenotypes to elucidate pathogenic drivers and etiologies.
To assist in the design of genomics experiments.
To analyze publicly available and novel genomic data sets (e.g., long-read DNA and RNA), including quality control, variant identification, annotation, and association with clinical/neuropathological outcomes using existing computational resources in R and other programs.
To work toward development of independent scientific ideas and postdoctoral-appropriate grants (e.g., K award, R03), with a long-term goal of independent investigator status.
The applicant must have:
Experience with genetics and a recent doctoral degree (e.g., Ph.D.) in computational biology, computer science, genetics, epidemiology, biostatistics, bioinformatics, or related field. Alternatively, an M.D. with additional relevant computational experience.
Expertise in R and R/Bioconductor and a scripting language (e.g., perl/python) in a Unix environment.
An interest in working with a diverse group of scientists to advance understanding of neurodegenerative diseases through a synergy of wet and dry lab approaches.
Chartered in 1963, the Icahn School of Medicine at Mount Sinai is the sole medical school for the Mount Sinai Health System which comprises seven hospital campuses and numerous ambulatory centers. The Icahn School of Medicine has more than 5,000 faculty and nearly 2,000 students, residents and fellows.
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