Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Principal Scientist to work on the Remyelination and Neuroprotection team. This team focuses on finding, validating and developing therapies for the treatment of Multiple Sclerosis (MS) and other disorders. This laboratory based position will include the opportunity to lead project teams and interact with internal and external functions to initiate new drug discovery programs and advance ongoing projects. The candidate must have a thorough understanding of and experience with neuronal and glial cell cultures and biology of myelination/demyelination/remyelination.
KEY TASKS & RESPONSIBILIITES:
Lead projects of high complexity as a project team leader, driving them from conception to development candidates.
Establish in vitro cell-based models of neuron-glia interactions including: myelinating cultures of mixed cortical neuron-glia, cerebellar and cortical tissue explants.
Establish in vitro cell –based models of neuronal cell death in response to insults, including oxidative, excitotoxic and ionic imbalances.
Conduct in vivo experimental work in animal models of MS, e.g. demyelination/remyelination and immune-driven models.
Conduct laboratory research on projects for the team and the Neuroscience Research Therapeutic Area.
Contribute to strategic and tactical selection and execution of targets for MS.
Interact with cross functional groups and other MS team members in France and US research facilities.
Efficiently collaborate with scientific staff within various groups including Chemistry, DMPK, Translational Sciences, Immunology and Inflammation in the US and EU.
Prepare and communicate results at external meetings and in publications of high quality.
Establish and maintain a scientific network external to the company for access to cutting edge technology and information to facilitate internal programs.
Ph.D. in Neuroscience or related field, with postdoctoral training. At least 3-5 years of research experience in MS and/or neurodegenerative diseases in biopharma strongly preferred.
Strong track record of publications in neuroscience, neuroimmunology, neurodegeneration and/or MS.
Understanding of neuronal and glial cell biology and pathology of MS and relevant animal models.
Experience in establishing and using neuronal models in vitro for drug discovery.
Ability to isolate subsets of neurons and establish primary cultures, including co-cultures and myelinating cultures.
Experience with in vitro electrophysiology of cultured neurons strongly preferred.
Experience in in vitro pharmacology, including dose response, PK/PD, kinetics, mechanism of action and preclinical proof of concept studies.