College / University, Hospital, Public and Private, Public Health
The Department of Pharmacodynamics at the University of Florida (UF) seeks a highly self-motivated research scientist with experience in primary cell and tissue models to work in a molecular pharmacology laboratory. Research in the principal investigator’s laboratory seeks to implement improved in vitro cell based systems to better predict human drug efficacy particularly for age-related diseases by leveraging the physiological relevance of patient-specific cells in combination with phenotypic microscopy and chemogenomic approaches to measure changes in responses to physical stressors. This scientist will utilize cellular and molecular pharmacological methods and work closely with the biomedical engineering department at UF and a millifluidic technology and implementation company to develop a tissue chip to investigate electrical stimulation of human skeletal muscle myocytes in microgravity as part of the Tissue Chips in Space Initiative funded by the National Center for Advancing Translational Science (NCATS) in partnership with the Advancement of Science in Space (CASIS). https://ncats.nih.gov/tissuechip/projects/space2018. This position offers an exciting opportunity to be part of the Tissue Chip for Drug Screening Program and analyze and adapt existing methodologies to create a novel microphysiological system to study the effects of microgravity on muscle cell biology.
Job Duties Include:
Design laboratory experiments, oversee their execution, and review/interpret results. This includes: immunofluorescent assays, kinetic cell viability and proliferation readouts, protein expression, light and confocal microscopy, molecular biology including RT-PCR.
Culture and maintain primary muscle lines isolated from phenotyped adult biopsies
Compile and analyze data. Adjust experimental designs based on experimental data analysis.
Maintain laboratory protocols and develop protocols to improve existing techniques.
Contribute as needed to writing manuscripts and grant applications
Help with organization of the laboratory and its equipment.
Manage data and protocol across teams and/or monitor quality of team's work.
Provide mentorship to junior members of the team as needed.
Maintain laboratory safety programs and train personnel in laboratory safety techniques.
Maintain accurate laboratory records.
Ph.D. in Biological Sciences, Pharmacology, Chemistry, Biomedical Engineering or related field and two years or relevant experience; or a master's degree in biology or a closely related field and five years of relevant experience; or a bachelor's degree in biology or a closely related field and seven years of relevant experience. Applicants should have excellent communication and problem-solving skills.
Working knowledge of in vitro drug efficacy assays related to musculoskeletal disease
Experience with electrical stimulation of cells.
Working knowledge of RNA transcriptomic approaches and gene expression profiling and analysis using software such as iPathway Guide
Experience performing RT-qPCR experiments.
Experience with High Content analysis.
Creative, possess an exceptional work ethic, and be able to complete experiments and data analysis independently and efficiently.
Strong communicator able to contribute to a multi-disciplinary team.
US citizenship is preferred as this program is partly funded under contract by NASA and involves access to government flight facilities.
Internal Number: 509250
About University of Florida, College of Pharmacy
University of Florida- College of Pharmacy
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