The Primary Pharmacology Group at our Groton campus is composed of ~50 scientists that support hit identification and lead optimization activities for small molecule drug discovery programs through the design, development, and execution of in vitro plate-based screening assays. Research Units supported by the group include Inflammation and Immunology, Cardiovascular/Metabolic, Rare Diseases, Oncology and our Center for Therapeutic Innovation. We typically drive small molecule programs from initiation through clinical candidate selection.
The successful candidate will join a multidisciplinary lab that, in addition to our core Pharmacology deliverables, is also applying cutting-edge DNA-Encoded Library (DEL) technology to discover starting points for small molecule projects. As a primary responsibility, (s)he will collaboratively partner with project teams to deliver hit identification efforts with DEL. In addition, (s)he will also provide pharmacology assay development and screening support for small molecule programs.
Applicants must be excited by new technology, have experience working independently in a laboratory setting, and an established record of success in a team-based scientific environment. Previous experience in 2 or more of the following is required: plate-based pharmacology, analytical (bio)chemistry, chemical biology, cell biology, biochemistry, enzymology, drug discovery, laboratory automation, DNA encoded library selection. Also critical to the role is a demonstrated ability to rapidly become proficient with new technologies, equipment and software (e.g. screening techniques and equipment, ActivityBase, GraphPad Prism, Spotfire).
The successful candidate will be excited by working in teams with multiple partners (e.g. Bioanalysis, Chemistry, Research Unit Biology, Structural Biology, and CROs). The candidate should therefore possess strong collaborative, written and verbal communication skills; and be adept at building partnerships. Key to the role is an ability to work autonomously and propose creative approaches for complex assay development and pharmacology questions. As such, in addition to technical skills, (s)he should demonstrate a personal drive, leadership skills, flexibility/resiliency, and a good sense of humor.
At Pfizer, we believe in helping people lead healthier lives — from our customers to our colleagues. We offer a wide array of programs and plans that give our colleagues the flexibility and tools they need to get and stay healthy, both physically and financially. These include competitive compensation, generous medical, vacation and retirement benefits plus additional programs. The Assay Development and Pharmacology group offers a collegial and supportive environment for colleagues, with a culture encouraging openness, innovation and ownership of our science. We aim to provide scientific and growth opportunities for personal and career development commensurate with a colleague’s goals and experience.
The scientist will apply fundamental techniques in biochemistry to characterize and validate targets for DNA-encoded library screening campaigns (including SDS-PAGE, western blot, enzyme and receptor binding assays). (S)he will conduct DNA-encoded library campaigns (affinity selection, qPCR analysis, SDS-PAGE, PCR), prepare samples for Next-Gen Sequencing, and partner with the colleagues in other departments who will conduct both NGS as well as DEL data analysis.
This scientist will participate in designing in vitro pharmacology strategies for projects. (S)he will design, optimize, and perform in vitro assays to drive lead identification and SAR using a combination of biochemical, target-based, and physiologically relevant assay systems. (S)he will carry out data analysis as well as review and interpret this data for project teams.
This scientist will apply cutting-edge technologies to effect portfolio advancement, is expected to have a drive for both personal growth and will provide mentorship to junior colleagues within the team.
This scientist will work with an interdisciplinary team of Research Unit biologists, medicinal chemists, structural biologists and biophysicists, as well as external partners to deliver on the portfolio.
BS or equivalent with 8+ years of experience relevant to drug discovery in chemistry, biochemistry, biology, and/or pharmacology OR MS with 5+ years of relevant industry experience
Demonstrated experience with several in vitro assay formats, including troubleshooting (examples: LC-MS, HPLC, FRET, FACS, FP, ELISA, high content imaging, FLIPR, radioligand binding, etc.)
Practical experience with gel-based techniques, cell culture, laboratory automation, and data analysis systems
A commitment to timely delivery and quality of the work product, overcoming obstacles in a fast-paced environment and a continuous improvement mind-set.
Demonstration of excellent computer, verbal and written communication skills
Hands-on molecular biology experience (PCR), familiarity with qPCR and Next Gen Sequencing is a plus.
Previous experience in multiple target classes in a drug discovery setting (e.g. GPCRs, transporters, kinases, ion channels)
Knowledge of associated disciplines such as protein chemistry, bioanalytical chemistry, molecular and cellular biology, biophysical techniques and chemistry.
Demonstrated ability to forge strong collaborative relationships inside and outside organizational walls and across multiple cultures: academic, industrial, and CROs.
A comfort with script-based data analysis and handling large datasets on platforms beyond Microsoft Excel
Sitting, standing, lifting, bending, and walking.Ability to perform practical laboratory bench work and work on a computer (while standing or sitting).
Ability to perform mathematical calculations and interpret data.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Candidate may periodically be asked to travel to the Pfizer Cambridge, MA and Pearl River, NY sites to meet project team members (2-4 times per year).
Candidate must comply with laboratory safety practices and wear personal protection as required.
Eligible for Relocation Package
Eligible for Employee Referral Bonus
Internal Number: 4751238
About Pfizer, Inc.
Pfizer is a leading research-based biopharmaceutical company. We apply science and our global resources to deliver innovative therapies that extend and significantly improve lives. We make medicines and vaccines that help people when they are sick and prevent them from getting sick in the first place, as well as some of the world’s best-known consumer healthcare brands. Every day, our colleagues work in developed and emerging markets to treat, cure and eradicate life-threatening conditions and challenge some of the most feared diseases of our time. Pfizer also collaborates with healthcare providers, governments and local communities to support and expand access to reliable, affordable healthcare around the world. For more than 150 years, Pfizer has worked to make a difference for all who rely on us. To learn more, visit www.pfizer.com. For additional information on our guidelines, please visit http://www.pfizer.com/community-guidelines