Duties/Responsibilities: This position is available with the U.S. Department of Health and Human Services, Food and Drug Administration (FDA), National Center for Toxicological Research (NCTR), Division of Neurotoxicology.
This position will serve as a principal scientist working in the Division’s neurohistological laboratory and will be responsible for designing and conducting neurotoxicological research studies for which they are Principal Investigator or Co-Investigator. The candidate’s research is focused on the assessment of the potential neurotoxicity of FDA-regulated products in the central (CNS) and peripheral nervous systems (PNS), the exploration of the underlying mechanisms, and addressing the clinical relevance of the laboratory findings as well as pursuing neuroprotective strategies. The studies are conducted primarily using in vitro and in vivo models.
The candidate constructs hypotheses based on their knowledge of the neurotoxicological literature and the Agency’s needs. They design, plan and execute appropriate experiments to test those hypotheses. Those experiments directly address issues of importance to the Agency. To implement these efforts, established, new and/or improved techniques are applied for the high throughput detection and automated quantification of anatomical, neuropathological, and histological endpoints in the CNS and PNS. The candidate advises and provides consultation to technical and other scientific personnel in the conduct of highly specialized techniques including, but not limited to, neurohistological and neuropathological assessments.
The candidate is responsible for disseminating the findings of their studies to the FDA, other governmental institutions, and academia through publications in quality scientific journals and presentations at scientific meetings. The candidate will provide guidance and collaborate with other scientists on the development and implementation of those techniques and will also:
Assist in training members of the laboratory in new techniques and methodologies
Analyze data, interpret results, and prepare manuscripts based on experimental findings
Prepare and present laboratory findings within the Center and at national and international conferences
Critically review manuscripts for other scientists within the Center and for the editorial boards of scientific journals
Maintain current knowledge of research and developments specifically related to regulatory research.
Candidates must submit a CV, a brief statement of interest, and two letters of recommendation to:
Desired Qualifications: Our ideal candidate must be knowledgeable in a variety of cellular and molecular biological, immunological, and computer-image analytical techniques. Specific research skills that are desired in the candidate include: a proven record of neurotoxicity assessment (using in vivo and in vitro methods), assessment of neuroanatomy with routine staining (H&E, etc.), immunohistochemistry (light, fluorescence, and confocal microscopy experience) and in situ hybridization for the localization of mRNA in brain tissue. Knowledge of electron microscopy is preferred.
Conditions of Employment: Ethics Requirements: This position is subject to strict prohibited financial interest regulations which could restrict the type of financial interest (stock holdings) for the employee, the spouse, and minor children of the employee. Selectee for this position will be required to file a Confidential Disclosure Report (OGE 450) and may require the selectee to obtain clearance from the FDA Division of Ethics and Integrity before a final offer can be made. For additional information on the prohibited financial interests, please visit the FDA Ethics and Integrity Office website at http://www.fda.gov/AboutFDA/WorkingatFDA/Ethics/default.htm.
Internal Number: FDA/NCTR-Neuropathology
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