The University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado
The Department of Pediatrics, Section of Genetics and Metabolism at The University of Colorado Anschutz Medical Campus seeks two laboratory directors ABMGG-certified in Molecular Genetics or Laboratory Genetics as part of an exciting expansion of genetic and personalized/precision medicine research in the Department of Pediatrics. Candidates at all academic levels will be considered. Successful candidates may become trainers in the LGG Fellowship and the Human Medical Genetics and Genomics Program of the Graduate School, as appropriate.
Nature of Work
The Section of Clinical Genetics and Metabolism, Department of Pediatrics, at the University of Colorado at Denver is recruiting a full-time PhD and/or MD molecular genetics director for the Precision Diagnostics Laboratory (PDL) at the Children’s Hospital Colorado. The candidate should be ABMGG board-certified or board-eligible in Clinical Molecular Genetics and Genomics or Laboratory Genetics and Genomics. This position is primarily aimed at supporting the clinical activities of the lab, as related to constitutional testing, through leadership, quality, interpretation and reporting, development of clinical interpretation workflows, and clinical support for assay development.
Knowledge, Skill, and Abilities
Experience with interpretation and results reporting for large NGS panels, ideally whole exome sequencing.
Broad knowledge of genetic variant databases and their utility.
Understanding of interpretation and reporting workflows.
Basic knowledge of NGS wet-bench techniques, data quality, and bioinformatics tools.
Understanding of laboratory quality measures and familiarity with CAP and CLIA regulations.
Ability to work in a collaborative team environment with clinical, scientific, and operational teams.
Desire to participate in the building of a clinical molecular genetics service.
Examples of Work Performed
Collaborate with PDL and Department of Pathology and Laboratory Medicine leadership, PDL scientific director, section manager, and technical staff as appropriate for optimal operations in the context of the entire laboratory and the hospital as a whole. Represent clinical interests in discussions regarding staffing, financial planning, quality, strategy, etc.
Provide clinical expertise in interpretation of molecular genetics laboratory test results as appropriate, including signing out interpretative reports.
Provide direction and insight regarding clinical needs related to appropriate laboratory testing for diagnosis and patient management.
Serve as a clinical consultant during the validation of new assays, with a focus on ensuring the assay serves the anticipated clinical needs, development of assay content, and developing interpretation workflows and procedures.
Depending on interest and experience, may take on more technical and scientific roles in assay development and validations under the guidance of the PDL scientific director.
Support laboratory quality through participation in investigations of quality issues and review of laboratory section procedures, assay verifications and validations, and proficiency testing results.
Assess the need for implementation of new assays or for retiring established assays based on clinical need, test volume, or improved technology. Recommend improvements in the laboratory section’s current assays, possible new assay offerings, and equipment needs.
Participate in the ongoing education of medical technologists, trainees of all types, and colleagues in their specific discipline. The laboratory is an active component of the ABMGG Laboratory Genetics and Genomics program, and the director will be expected to be active in that training program.
Although this is primarily a clinical position, opportunities for collaborative research abound, and moderate dedicated research time for funded investigators is available (and encouraged).
MD or PhD with ABMGG certification in Clinical Molecular Genetics and Genomics or Laboratory Genetics and Genomics and at least 5 years of clinical molecular lab work experience after completion of training.
Internal Number: PDx001
About University of Colorado Anschutz Medical Center
As one of 4 campuses of the University of Colorado System, CUAMC is a new campus designed to be a home to biomedical research and education in all areas. CUAMC is home to the Children’s Hospital Colorado flagship location, the University of Colorado Hospital flagship location, the new Veteran’s Administration Hospital, the School of Medicine, the Skaggs School of Pharmacy and Pharmaceutical Science, the School of Dental Medicine, the College of Nursing, and the multi-campus Colorado School of Public Health. CUAMC is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The University strives to promote a culture of inclusiveness, respect, communication and understanding.