The Rumbaugh Lab at The Scripps Research Institute in Jupiter, Florida is seeking to fill multiple postdoctoral positions.
One project focuses on how major autism risk factors impact brain function in rodent and human patient iPSC models. Approaches include whole cell patch-clamp, two-photon imaging, and in vivo physiology in behaving animals paired with machine learning measurements of multidimensional behavior.
The other project is cell-biology oriented and related to ongoing high-throughput screens for small molecule regulators of genes linked to severe neurodevelopmental disorders. This trainee will focus on the molecular mechanisms of mRNA stability, mRNA translation, and protein degradation of genes that cause monogenic neurodevelopmental disorders. Model organisms include humanized rodents and iPSCs derived from patients with neurodevelopmental disorders. Assays will include microscopy of living neurons and electrophysiology
For both positions, successful candidates will have recently received (or soon will receive) a Ph.D. degree, have a strong publication record and have prior experience with either neuronal cell biology concepts and techniques or systems neuroscience techniques. Computer programming skills (e.g. MatLAB; PYTHON) are desired. Please visit the laboratory website at:
To apply, please send CV, brief description of research interests and contact information of references to Dr. Gavin Rumbaugh at gavin@scripps.edu. The Scripps Research Institute provides an outstanding intellectual environment and access to a wide range of cutting-edge technologies. TSRI embraces diversity and recognizes it as being the key to our success. EOE/M/F/V/D
NOTES:
2 openings.
Additional Salary Information: Scripps Research follows the NIH/NRSA current salary guidelines for postdoctoral employees based on their years of experience.
Internal Number: 05966
About The Scripps Research Institute
The Scripps Research Institute (TSRI), one of the world's largest, private, non-profit research organizations, stands at the forefront of basic biomedical science, a vital segment of medical research that seeks to comprehend the most fundamental processes of life. Over the last decades, the institute has established a lengthy track record of major contributions to the betterment of health and the human condition.
The institute — which is located on campuses in La Jolla, California, and Jupiter, Florida — has become internationally recognized for its research into immunology, molecular and cellular biology, chemistry, neurosciences, autoimmune diseases, cardiovascular diseases, virology, and synthetic vaccine development. Particularly significant is the institute's study of the basic structure and design of biological molecules; in this arena TSRI is among a handful of the world's leading centers.
Rather than isolating faculty members, students, and laboratories into separate and distinct disciplines, as is generally prescribed in universities, a cooperative, collaborative spirit is encouraged and embraced. While the level of scientific investigation is intense, the atmosphere... is collegial, relaxed, and informal. Technicians, postdoctoral fellows, graduate students, and administrative support staff all are considered part of the team and are given the latitude and responsibility to accomplish their tasks so as to serve the best interests of science. The pursuit of scientific excellence is paramount and all efforts are directed toward that end.
The bulk of the institute's funding is derived from the National Institutes of Health and other federal agencies. In today's environment of increasing competition for shrinking federal dollars, however, collaborative industrial partnerships with leading pharmaceutical companies provide additional funding in several areas key to the organization's research objectives.
The Scripps Research Institute's adherence to the highest scientific standards, emphasis on a multidisciplinary approach to problem solving, participation in the perpetuation of knowledge through education, and continual pursuit of research excellence provide an unparalleled scientific environment.
