Highly motivated candidates are invited to lead several new projects to address fundamental questions on neuronal differentiation, migration and maturation,in particular with regard to inhibitory neurons,related to the neurodevelopmental component of major psychiatric diseases including schizophrenia, bipolar disorders and major depression disorder.Experimental approaches, including biochemistry, genetics, cell biology, live cell imaging and electrophysiology are employed on iPSC-derived neurons coming from unique high-risk cohorts composed of both patients suffering from major psychoses and their high-risk offspring.
Thus, the project is part of a highly competitive research endeavor, and offers excellent perspectives for scientific career development.
We offer a great team spirit within a interdisciplinary environment , state-of-the-art equipment and work technology (new cutting-edge multimodal live cell imaging, a large library of recombinant AAV vectors expressing fluorescent sensors, availability of core units for proteomics and transcriptomics, etc.).
Under the supervision of the principal researcher, the candidate will have to perform the following tasks, among others, with the help of laboratory technicians:
Developing and optimizing protocols for the neural differentiation of human iPSCs.
Design and perform experimentson humaniPSC-derived neuronal cells with different techniques including ICC, FACS, qPCR, wester blot, single cell analysis, as well as multimodal super-resolution live cell imaging developed in the Laboratory
Write and review of scientific articles
To maintain knowledge of current developments in the field of research notably by attending international congresses and workshops.
Ph.D. in neurobiology, developmental neuroscience, stem cell biology or related fields. Additionally,the successful candidate will have proven solid experiences with iPSC-derived cell culture, ideally has already differentiated such cell lines into neurons, and is also experienced with, immunocytochemistry and molecular biology.Knowledge in the field of live cell imaging and/or electrophysiology is an asset.
Internal Number: PM_59
About CERVO Brain Research Centre
The CERVO Research Center, one of Canada's leading neuroscience and mental health centers, focuses on the root
The CERVO Research Center, one of Canada's leading neuroscience and mental health centers, focuses on the root causes of brain diseases. It brings together some sixty researchers in charge of research teams with more than 400 people, offering multidisciplinary expertise, ranging from membrane biophysics to social intervention, and the psychology of cognition.
The CERVO Research Center is devoted exclusively to the study of neurosciences and mental health. Its mission is to advance knowledge about the causes and treatment of neurological and psychiatric illnesses by developing new technologies and methodologies to unravel the mysteries of the brain and by continuously linking basic and clinical research.
The CERVO centre tackles the root causes of brain diseases, whether neurological or psychiatric, because they all share many common mechanisms. It is distinguished by high-caliber scientific activity and technological development efforts in the service of science and health, thus maintaining hope for our patients and contributing significantly to destigmatizing mental illness, to the greatest benefit of patients.
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