Details
Posted: 05-May-22
Location: Cincinnati, Ohio
Salary: Open
DescriptionJOB DESCRIPTION:The Spearman laboratory seeks a postdoctoral investigator to work on the interaction of HIV with cells of the central nervous system (CNS). The interactions of HIV with microglia and potentially other cells in the CNS are likely to modulate the occurrence of HIV-associated neurocognitive disorders (HAND). We are studying HIV-infected microglia and developing cerebral organoid models for the study of HIV interactions with and effects on the brain. Our work on the development of iPSC-derived microglia as an HIV infection model was recently published in Retrovirology [PMID 33213476]. The ideal candidate for this position will have a doctoral degree and experience with tissue culture, use of molecular techniques, and the design of creative experiments. Valuable experience would include culturing of induced pluripotent stem cells (iPSCs), microscopic skills including immunofluorescence analysis, and analysis of cell types and activation using transcriptomics.
Cincinnati Children's Research FoundationCincinnati Children's Hospital Medical Center (CCHMC) is a premier
pediatric research institution with over 900 diverse and productive faculty members. Here, researchers work collaboratively across specialties and divisions to address some of the biggest challenges we face today in improving child health. A strong network of research support
services and
facilities, along with institutional commitment to research, push our team of faculty, postdocs and support staff to explore the boundaries of what is possible, leading to
significant breakthroughs. We are driven by our mission to improve child health and transform the delivery of care through fully integrated, globally recognized research, education and innovation.
Post-doctoral Research Fellows at Cincinnati Children's are valued for their unique interests and strengths, and are supported by our institution's
strong programming for post-docs through the
Office of Postdoctoral Affairs and the
Office of Academic Affairs and Career Development. Cincinnati Children's is a respected part of the broader, and very vibrant, Cincinnati community. With a thriving arts scene, numerous festivals celebrating music and food, a passionate fan following for our college and professional sports teams, and a variety of opportunities for outdoor activities,
our region is truly a great place to work and live.
REPRESENTATIVE RESPONSIBILITIES1. Design, execute, and record laboratory experiments; apply standard scientific protocols to experiments, research, and improve current methods and evaluate innovative techniques.
2. Draft, write, and edit scientific reports, papers, journal articles, and abstracts.
3. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments.
4. Develop, set-up, and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats.
5. Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis.
6. Maintain an integral role in the laboratory's meetings, presentations, and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs, and seminars.
7. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel.
8. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks.
9. Assist in preparing, writing, and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests; track funding, maintain accurate balance, and resolve any discrepancies.
10. Follow policies and procedures governing the handling of confidential information as defined by Cincinnati Children's mission and applicable laws and regulations. Ensure timeliness, accuracy, availability, and security of information.
11. Perform routine procedures, including the collection and analysis of research data, which may affect decisions regarding future patient care.
12. Provide services in a manner to be regularly and conveniently available to meet the needs of Cincinnati Children's research initiatives as determined by department management and Cincinnati Children's governing body.
13. Maintain currency in field through continuing education, literature and seminars. Implement this knowledge into the Department.
14. Recommend approaches for improvement activities, recommend and perform new processes, collect and measure data, develop processes based on performance, and communicate results.
15. Ensure that work areas are organized and present a safe, accessible, effective and efficient environment. Manage attendance at required Cincinnati Children's training sessions, including radiation safety, laboratory safety, bloodborne pathogens, and OSHA. Comply with Infection Control policies and procedures.
16. Participate in establishing job requirements and goals; perform duties at the desired level of competency.
17. Understand, adhere to, and model Core Standards as defined organizationally and specifically within the department/unit.
18. Perform other duties as assigned.
QualificationsEDUCATION/EXPERIENCERequired: PhD, MD or equivalent doctoral degree
Preferred: The ideal candidate for this position will have experience with tissue culture, use of molecular techniques, and the design of creative experiments. Valuable experience would include culturing of induced pluripotent stem cells (iPSCs), microscopic skills including immunofluorescence analysis, and analysis of cell types and activation using transcriptomics.
