University of California, Davis, Department of Psychiatry and Behavioral Sciences
Application
Details
Posted: 01-Aug-22
Location: Sacramento, California
Type: Full Time
Required Education: Doctorate
Sector:
Hospital, Public and Private
College / University
Preferred Education:
Doctorate
Internal Number: Job #JPF05098
The University of California, Davis, Department of Psychiatry and Behavioral Sciences is recruiting for an Assistant Professional Researcher. The candidate for this position will provide significant, original, and creative contributions to a creative research project in the relevant academic discipline of the study of modeling of Neurodevelopmental disorders (NDDs). The candidate will develop an independent research program using mouse models to study the molecular mechanisms and multi-omic signatures, neurodevelopmental and anatomical perturbations, and synaptic, circuit, and behavior outcomes that are associated with genetic and environmental risk factors underlying NDDs.
I. RESEARCH (90%) The specific focus of this research program will be : a) to investigate the factors that contribute to the causal neurobiology of CHD8 haploinsufficiency and other monogenic forms of NDDs, b) investigate gene be environment interactions, in particular preclinical rodent models of Maternal Immune Activation (MIA) and Maternal Auto-Antibody (MAA) exposure, c) to apply region- and cell-type specific analysis to these genetic and environmental models, with particular focus on neuronal subtypes and on the contributions of cerebral cortex and cerebellum, d) to develop and apply -omics strategies for unbiased and directed systems-level modeling applied to developing and mature brain, including bulk and single cell and single nucleus transcriptomics and epigrenomics and shotgun proteomics with mass spectroscopy, and spatial transcriptiomics via RNA-FISH and emerging In Situ Sequencing approaches, e) to drive major research programs associated with currently funded and future collaborative research projects, and f) contribute to and draft new grant applications and secure funding to carry out new research projects.
It is anticipated that the development and implementation of the relevant research program will entail submitting applications for extramural funding independently and in collaboration with other faculty members primarily in the UC Davis Center for Neuroscience, the Genome Center, the Department of Psychiatry and the MIND Institute, as well as other departments and programs in UC Davis. Anticipated sources of funding include the National Institute of Health, foundations, UC Davis internal opportunities as well as other similar research funding initiatives. These extramural projects will involve developing new research protocols, administering protocols, and collecting and analyzing data.
Technically, they will also include the ability to perform advanced protein biochemistry techniques, neuroanatomy, and gene expression analyses, as well as data management and quality assurance. Training and management of staff and UC Davis trainees will also be involved.
This position will also be responsible for training and managing the staff, post and predoctoral trainees and students, as well as overseeing budget allocation and reporting requirements of the above-mentioned research projects, and research projects under any additional new grants they might secure.
II. PROFESSIONAL COMPETENCE AND ACTIVITY (5%)
The candidate will continue to participate as a member of professional societies, such as the Society for Neuroscience (SfN), American Society of Human Genetics (ASHG) and the International Society for Autism Research. It is also anticipated that they will present the results of their research at national and international scientific meetings such as SfN, ASHG, MPA and ISDN.
The candidate is expected to serve occasionally as a reviewer of research proposals and scientific publications as appropriate. They will attend Center for Neuroscience, Genome Center, Mind Institute and department seminars to present research results. They also will participate in joint lab meetings with other faculty labs at the Center for Neuroscience and the Genome Center groups as appropriate (i.e. Fioravante, McAllister, Whistler, Dennis labs).
III. UNIVERSITY AND PUBLIC SERVICE (5%)
The candidate will engage in university service activities such as guest lecturing and committee service for the Department and the Center for Neuroscience, including outreach to the general public and Sacramento region community. They will also commit to an active role in university service by supervising undergraduate student researchers mostly from Neurobiology, Physiology and Behavior Major (NPB) and serving as a member of scholarly selection committees for the College of Biological Sciences.
This recruitment is conducted at the Assistant rank. The selected candidate will be hired at the Assistant rank, regardless of the proposed appointee's qualifications
The Department of Psychiatry has approximately 60 residents in six residency training programs and 90 faculty and staff psychiatrists and psychologists. The Department provides a stimulating teaching and academic environment and serves a culturally diverse population.
QUALIFICATIONS
Basic qualifications (required at time of application)
Qualified candidates must possess a Ph.D. (awarded in the past 10 years) in Medical Sciences, Developmental Neuroscience, Human Genetics or a related field; and formal degree training biochemistry, genetics, and neuroanatomy.
A minimum of 5 years of experience beyond the Ph.D.
The applicant will have a background in leading complex research projects, including supervising employees in the afore mentioned disciplines; as well as a history of conducting research in specific applied techniques relevant to the analysis of genetic and environmental factors involved in neuropsychiatric and complex neurodevelopmental disorders.
Expertise working with DNA and RNA, protein biochemistry, neuroanatomy, cell culture, gene expression analysis, and immunohistochemistry and RNA FISH.
Expertise in genetic and environmental mouse models of NDDs, including generation and validation of new models, husbandry including breeding, colony management, and setting up timed matings for embryonic tissue collection.
Experience with single cell/nucleus RNA Sequencing (scRNA-seq) applied to ex vivo brain tissues, including microdissection of specific brain regions from embryonic and postnatal rodent brain, preparation of single cell an nucleus suspensions, generation of sequencing libraries, and expertise in computational analysis using established platforms including CellRanger and Seurat.
Experience and interdisciplinary training in autism spectrum disorder and/or more generally, NDDs.
Excellent references related to the ability to work in a team and collaboratively with peers.
APPLICATION REQUIREMENTS
Document requirements
Curriculum Vitae - Your most recently updated C.V.
Cover Letter (Optional)
Statement of Research
Statement of Teaching (Optional)
Statement of Contributions to Diversity, Equity, and Inclusion - Contributions to diversity, equity, and inclusion documented in the application file will be used to evaluate applicants. Visit https://academicaffairs.ucdavis.edu/faculty-equity-and-inclusion for guidelines about writing a statement and why one is requested.
We are an Affirmative Action/Equal Opportunity employer, and particularly encourage applications from members of historically underrepresented racial/ethnic groups, women, individuals’ with disabilities, veterans, LGBTQ community members, and others who demonstrate the ability to help us achieve our vision of a diverse and inclusive community. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct
Under Federal law, the University of California may employ only individuals who are legally able to work in the United States as established by providing documents as specified in the Immigration Reform and Control Act of 1986. Certain UC Davis positions funded by federal contracts or sub-contracts require the selected candidate to pass an E-Verify check. More information is available at: http://www.uscis.gov/e-verify
As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees should refer to Appendix F, Section II.C. of the policy for applicable deadlines. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.
Basic qualifications (required at time of application)
Qualified candidates must possess a Ph.D. (awarded in the past 10 years) in Medical Sciences, Developmental Neuroscience, Human Genetics or a related field; and formal degree training biochemistry, genetics, and neuroanatomy.
A minimum of 5 years of experience beyond the Ph.D.
The applicant will have a background in leading complex research projects, including supervising employees in the afore mentioned disciplines; as well as a history of conducting research in specific applied techniques relevant to the analysis of genetic and environmental factors involved in neuropsychiatric and complex neurodevelopmental disorders.
Expertise working with DNA and RNA, protein biochemistry, neuroanatomy, cell culture, gene expression analysis, and immunohistochemistry and RNA FISH.
Expertise in genetic and environmental mouse models of NDDs, including generation and validation of new models, husbandry including breeding, colony management, and setting up timed matings for embryonic tissue collection.
Experience with single cell/nucleus RNA Sequencing (scRNA-seq) applied to ex vivo brain tissues, including microdissection of specific brain regions from embryonic and postnatal rodent brain, preparation of single cell an nucleus suspensions, generation of sequencing libraries, and expertise in computational analysis using established platforms including CellRanger and Seurat.
Experience and interdisciplinary training in autism spectrum disorder and/or more generally, NDDs.
Excellent references related to the ability to work in a team and collaboratively with peers.
About University of California, Davis, Department of Psychiatry and Behavioral Sciences
The Department of Psychiatry and Behavioral Sciences at UC Davis has rapidly grown over the last several years, more than doubling the size of its faculty and staff to approximately 80 psychiatrists, psychologists, and scientists and approximately 300 employees. The Department's administrative offices, outpatient clinic, and education office are located at 2230 Stockton Blvd., directly across from the UC Davis Medical Center. The Department also has a child and adolescent psychiatry clinic located next door at 2348 Stockton Blvd. The Department's forensic division and psychosomatic medicine service are located at 2348 Stockton Blvd. Finally, a number of Department faculty are located at the MIND Institute and Imaging Research Center in Sacramento as well as the Center for Neuroscience on the UC Davis campus. The Department provides clinical services at a number of locations throughout the greater Sacramento area. The psychosomatic medicine service provides services in the main hospital. Outpatient services are provided on the first floor of the 2230 Stockton Blvd. site. Department faculty are assigned to the intake and inpatient psychiatry units at the Sacramento County Mental ...Health Treatment Center campus, located a block away at 2150 Stockton Blvd. Faculty and residents also provide services at three County of Sacramento regional clinics, a cross-cultural outpatient clinic, and a homeless mentally ill clinic, and the 2348 Stockton Blvd. child and Adolescent psychiatry clinic.