RESEARCH FELLOW - Systems Biology of HIV Infection
Cincinnati Children's Hospital Medical Center
Location: Cincinnati, Ohio
Internal Number: 137544
The Spearman and Hagan labs in the Division of Infectious Diseases at Cincinnati Children's Hospital are seeking a postdoctoral fellow in systems biology of HIV infection in the central nervous system and its role in the development of HIV-associated neurocognitive disorder (HAND). HIV infects brain macrophages and microglia early following acute infection. Neurological involvement in HIV pathogenesis is commonly associated with a spectrum of cognitive impairments. People living with HIV often develop cognitive, mood, and motor complications collectively recognized as HIV-associated Neurocognitive Disorder (HAND). This position will involve analysis of transcriptomic and epigenomic data from multidimensional stem cell model systems, including human cerebral organoids, to identify the microenvironmental changes imparted by HIV infection of microglia and their influence on neuroinflammation. This project involves close collaboration between computational and experimental labs, and strong communication and presentation skills are required.
Cincinnati Children's Research and Training at a Glance:
Among the top in NIH funding for pediatric research institutions
Over 1.4 million square feet of research laboratory space
900+ scientists conducting basic, translational, and clinical research
Over 2000 publications annually in top-tier journals
Access to Employee Resource Groups and Mentorship programs
Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.
-Conduct Research Design, execute, and record analysis and experiments; develop and apply standard scientific protocols to research, and improve current methods and evaluate innovative techniques. Develop and implement human subject research protocols, and design experimental procedures and documentation in accordance with the relevant laws and regulations. Prepare, clean and analyze data. Maintain optimal protocol and accuracy by conducting regular quality and reproducibility checks.
-Dissemination of research Draft, write and edit scientific reports, papers, journal articles and abstracts. Present at local, national and international scientific meetings.
Train and supervise the work of trainees in the program, as appropriate. Maintain an integral role in the group meetings, presentations and publications. Present information on research to others at group meetings, journal clubs and seminars. Demonstrate attendance and punctuality, ability to work independently & display initiative and dedication
May act as a mentor to more junior staff, serve as the contact for resolution of complex issues, provide education, guidance and work direction. May provide input and feedback to managers on hiring decisions, professional development and performance management.
Assist in preparing, writing and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve and initiate check requests; track funding, maintain accurate balance and resolve any discrepancies.
MAJOR DUTIES AND RESPONSIBILITIES: 1. Design, execute, and record laboratory experiments; apply standard scientific protocols to experiments, research, and improve current methods and evaluate innovative techniques. 2. Draft, write, and edit scientific reports, papers, journal articles, and abstracts. 3. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments. 4. Develop, set-up, and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats. 5. Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis. 6. Maintain an integral role in the laboratory's meetings, presentations, and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs, and seminars. 7. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel. 8. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks. 9. Assist in preparing, writing, and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests; track funding, maintain accurate balance, and resolve any discrepancies. 10. Follow policies and procedures governing the handling of confidential information as defined by Cincinnati Children's mission and applicable laws and regulations. Ensure timeliness, accuracy, availability, and security of information. 11. Perform routine procedures, including the collection and analysis of research data, which may affect decisions regarding future patient care. 12. Provide services in a manner to be regularly and conveniently available to meet the needs of Cincinnati Children's research initiatives as determined by department management and Cincinnati Children's governing body. 13. Maintain currency in field through continuing education, literature and seminars. Implement this knowledge into the Department. 14. Recommend approaches for improvement activities, recommend and perform new processes, collect and measure data, develop processes based on performance, and communicate results. 15. Ensure that work areas are organized and present a safe, accessible, effective and efficient environment. Manage attendance at required Cincinnati Children's training sessions, including radiation safety, laboratory safety, bloodborne pathogens, and OSHA. Comply with Infection Control policies and procedures. 16. Participate in establishing job requirements and goals; perform duties at the desired level of competency. 17. Understand, adhere to, and model Core Standards as defined organizationally and specifically within the department/unit. 18. Perform other duties as assigned.
Required: Doctoral degree in a related field Preferred: PhD in computational/systems biology, bioinformatics, computer science, or a related field. Fluency in at least one programming language (e.g. R, MATLAB, or Python) and competency in or willingness to learn immunology and HIV biology.
Cincinnati Children's is proud to be an Equal Opportunity Employer that values and treasures Diversity, Equity, and Inclusion. We are committed to creating an environment of dignity and respect for all our employees, patients, and families (EEO/AA).
About Cincinnati Children's Hospital Medical Center
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.